Understanding the Mechanisms That Regulate Infection-Induced Preterm Birth

Role of IRG1 in Regulating Pro-inflammatory and Pro-labor Mediators in Human Myometrium

R Lim, M Lappas

2020-01-01

Preterm birth is a major contributor to neonatal deaths and associated long-term morbidities for the survivors, yet therapies rema..

Expression and function of macrophage-inducible C-type lectin (Mincle) in inflammation driven parturition in fetal membranes and myometrium

R Lim, M Lappas

2019-07-01

The pivotal role of inflammatory processes in human parturition is well known, but not completely understood. We have performed a ..

Fetal membrane architecture, aging and inflammation in pregnancy and parturition

R Menon, LS Richardson, M Lappas

2019-04-01

Preterm birth is the single major cause of infant mortality. Short and long term outcomes for infants are often worse in cases of ..

Targeting bromodomain-containing proteins to prevent spontaneous preterm birth

R Lim, C Nguyen-Ngo, M Lappas

2019-01-01

Preterm birth is a global healthcare challenge. Spontaneous preterm birth (sPTB) is commonly caused by inflammation, yet there are..

Expression and regulation of metallothioneins in myometrium and fetal membranes

M Lappas

2018-12-01

Problem: Metallothioneins (MTs) play important roles in regulating oxidative stress, inflammation, and hormone signaling. These pr..

Potent anti-inflammatory effects of honokiol in human fetal membranes and myometrium

YK Wijesuriya, M Lappas

2018-10-01

Background: Preterm birth is the most prominent complication attributing to poor pregnancy and neonatal outcome. Infection is most..

Runt-related transcription factor 1 (RUNX1) deficiency attenuates inflammation-induced pro-inflammatory and pro-labour mediators in myometrium

M Lappas

2018-09-15

Identifying new targets that regulate myometrial activation are required to develop effective treatments to stop preterm labor. In..

The immunoproteasome inhibitor ONX-0914 regulates inflammation and expression of contraction associated proteins in myometrium

S Liong, R Lim, C Nguyen-Ngo, G Barker, HC Parkington, M Lappas

2018-08-01

There are currently no effective treatments to prevent spontaneous preterm labor. The precise upstream biochemical pathways that r..

Pellino 1 is a novel regulator of TNF and TLR signalling in human myometrial and amnion cells

R Lim, G Barker, M Lappas

2018-06-01

Preterm birth is the primary cause of neonatal deaths and morbidities. Pathological processes causally linked to preterm birth are..

NOD-like receptor pyrin domain-containing-3 (NLRP3) regulates inflammation-induced pro-labor mediators in human myometrial cells

R Lim, M Lappas

2018-04-01

Problem: Inflammation plays a major role in preterm birth. Nucleotide-binding oligomerization domain-like receptor pyrin domain-co..

DREAM Is Involved in the Genesis of Inflammation-Induced Prolabour Mediators in Human Myometrial and Amnion Cells

P Goradia, R Lim, M Lappas

2018-01-01

Preterm birth is the primary cause of perinatal morbidity and mortality worldwide. Inflammation induces a cascade of events leadin..

Identification of SMAD3 as a Novel Mediator of Inflammation in Human Myometrium In Vitro

Martha Lappas

2018-01-01

Preterm birth remains the primary cause of early neonatal death and is a major determinant for long-term health consequences. Aber..

Identification of Smad3 as a novel mediator of inflammation in human myometrium in vitro

M Lappas

2018-01-01

Preterm birth remains the primary cause of early neonatal death and is a major determinant for long-term health consequences. Aber..

IRF5 is increased in labouring myometrium and regulates pro-labour mediators

R Lim, G Barker, M Lappas

2018-01-01

Preterm birth continues to be the leading cause of neonatal mortality and morbidities that can extend into adult life. Few treatme..

Markers of protein synthesis are increased in fetal membranes and myometrium after human labour and delivery

S Liong, M Lappas

2018-01-01

Preterm birth remains one of the leading causes of neonatal death. Inflammation and maternal infection are two of the leading aeti..

PARK7 regulates infammation-induced pro-labour mediators in myometrial and amnion cells

R Lim, G Barker, M Lappas

2018-01-01

Preterm birth is a prevalent cause of neonatal deaths worldwide. Infammation has been implicated in spontaneous preterm birth invo..

The IL-1β signalling pathway and its role in regulating pro-inflammatory and pro-labour mediators in human primary myometrial cells

M Lappas

2017-12-01

Interleukin (IL)-1β plays a central role in the processes of human labour and delivery. The adaptor proteins involved in the IL-1β..

A20, an essential component of the ubiquitin-editing protein complex, is a negative regulator of inflammation in human myometrium and foetal membranes

M Lappas

2017-09-01

STUDY QUESTION: Does A20 regulate mediators involved in the terminal processes of human labour in primary myometrial and amnion ce..

SMAD7 regulates proinflammatory and prolabor mediators in amnion and myometrium

R Lim, G Barker, M Lappas

2017-08-01

Preterm birth continues to be a significant public health problem. Infection (bacterial and or viral) and inflammation, by stimula..

TLR2, TLR3 and TLR5 regulation of pro-inflammatory and pro-labour mediators in human primary myometrial cells

R Lim, G Barker, M Lappas

2017-08-01

Preterm birth continues to be a significant global health care issue, due to our lack of understanding of the mechanisms that driv..

Hepatitis A virus cellular receptor 2 (HAVCR2) is decreased with viral infection and regulates pro-labour mediators OA

S Liong, R Lim, G Barker, M Lappas

2017-07-01

Problem: Intrauterine infection caused by viral infection has been implicated to contribute to preterm birth. Hepatitis A virus ce..

TRADD, TRAF2, RIP1 and TAK1 are required for TNF-α-induced pro-labour mediators in human primary myometrial cells

R Lim, G Barker, M Lappas

2017-07-01

Problem: TNF-α plays a central role in the processes of human labour and delivery. This study sought to determine the role of the ..

Inhibition of PIMI kinase attenuates inflammation-induced pro-labour mediators in human foetal membranes in vitro

R Lim, G Barker, M Lappas

2017-06-01

STUDY QUESTION: Does proviral integration site for Moloney murine leukaemic virus (PIM)1 kinase play a role in regulating the infl..

The Adaptor Protein p62 Mediates Nuclear Factor B Activation in Response to Inflammation and Facilitates the Formation of Prolabor Mediators in Human Myometrium

M Lappas

2017-05-01

Preventing spontaneous preterm birth is one of the most important issues facing perinatal medicine today. The pathophysiology of p..

Optineurin suppression activates the mediators involved in the terminal effector pathways of human labour and delivery

R Lim, G Barker, M Lappas

2017-01-01

Spontaneous preterm birth remains the major cause of neonatal death and morbidity. Studies in non-gestational tissues report that ..

RKIP is decreased in laboring myometrium and modulates inflammation-induced pro-labor mediators

M Lappas

2017-01-01

Nuclear factor-kappa B (NF-ΚB)-induced inflammation plays a central role in the terminal process of human labor and delivery. Our ..

A novel role for SIRT3 in regulating mediators involved in the terminal pathways of human labor and delivery1

R Lim, G Barker, R Menon, M Lappas

2016-11-01

Preterm birth remains the major cause of neonatal mortality and morbidity, mediated largely by an inflammatory process. The sirtui..

ATF3 is a negative regulator of inflammation in human fetal membranes

R Lim, G Barker, S Liong, C Nguyen-Ngo, S Tong, T Kaitu'u-Lino, M Lappas

2016-11-01

Introduction Infection and inflammation stimulate pro-inflammatory cytokines, prostaglandins and matrix metalloproteinase (MMP)-9,..